One of the main means of treating diseases of the digestive tract are antiulcer drugs, in particular, antisecretory agents. The most commonly prescribed drugs include Ranitidine and Omeprazole.
Which is better Ranitidine or Omeprazole? What do these pills help with? Let's find out which drug is more effective, what advantages and disadvantages they have? Let’s take the instructions for both medications as a basis and study them carefully:
What does Omeprazole help with? ?
This medicine is one of the most modern means for reducing the aggressive effects of hydrochloric acid on the mucous membrane gastrointestinal tract. Increased acidity of gastric juice can provoke the development of gastritis and peptic ulcers.
Instructions for use define a specific list of diseases for which this medicine is effective:
Indications:
Gastritis, stomach and duodenal ulcers.
- Long-term treatment with drugs that have an aggressive effect on the gastrointestinal mucosa, in particular corticosteroids.
- Presence of heartburn, reflux esophagitis.
- Tumors of the stomach, pancreas.
- Suspicion or diagnosed systemic mastocytosis.
- Presence of oliendocrine adenomatosis.
Capsules are taken orally with clean water, before or during meals.
Contraindications and side effects
It is contraindicated to take the drug for pregnant and lactating women, as well as for those with intolerance to the components of this medicine.
Undesirable effects of taking Omeprazole include: allergic manifestations, dyspeptic reactions - stool disturbances, increased gas formation.
What does Ranitidine help with? ?
One of the oldest drugs on the pharmaceutical market intended for the treatment of the gastrointestinal tract. Many doctors consider Ranitidine an outdated drug.
Indications:
In accordance with the instructions, it is prescribed in the following cases:
Acute gastritis, peptic ulcer with high acidity, as well as for the purpose of prevention during the period of remission.
- Heartburn caused by stress or associated with poor nutrition.
- Reflux esophagitis.
Ranitidine is also used for gastroscopy (preparation for the procedure) and for surgical operations on the stomach.
Contraindications and side effects:
The medicine is contraindicated in children under 12 years of age, pregnant and lactating women. It is not prescribed to patients with hypoacid gastritis (low acidity) and with individual intolerance.
Undesirable effects from taking the drug include: allergic manifestations, dyspeptic reactions - stool disorders, nausea. During use, the following may occur: headache, arrhythmia, tachycardia and visual disturbances.
After discontinuation of the drug, patients may experience increased gastric secretion. Rapid addiction to the drug was also noted.
Drug prices
The average price of Ranitidine in Russia depends on the amount of active ingredient:
A package of 20 tablets with a dosage of 150 mg costs, on average, from 48 to 56 rubles;
- pack of 20 tablets, dosage 300 mg - from 248 to 265 rubles
The average price of Omeprazole is from 60 rubles to 183 rubles.
Ranitidine or Omeprazole - which is better??
Omeprazole belongs to the PPI group, and Ranitidine is an H2-blocker of histamine receptors.
Both drugs are antisecretory agents that block the active production of hydrochloric acid in the stomach. Thanks to this property, they are effective in the complex treatment of gastritis and peptic ulcers with high acidity.
However, Omeprazole not only blocks the production of hydrochloric acid, but also neutralizes its excess, promotes active healing of erosions and restoration of damaged mucosa.
Ranitidine is used for the same diseases as Omeprazole, associated with increased stomach acidity. The action of Ranitidine is also aimed at healing damaged mucosa.
The advantage of Omeprazole is the presence of a dosage form in the form
Powder for preparing a solution for intramuscular and intravenous injections.
Another advantage is its form - enteric capsules containing an enteral coating inside. The drug can also be presented in regular tablet form. Ranitidine is available only in the form of tablets for internal use.
Ranitidine is contraindicated in children under 12 years of age. Omeprazole can be taken from 5 years of age.
In addition, Ranitidine has a significant drawback - accelerated adaptation of the body to standard doses. After stopping this medication, patients experience a sharp increase in gastric secretion.
In general, according to experts, PPIs are considered more effective than H2 blockers. However, cases of so-called omeprazole resistance have been identified, when the drug has practically no effect on them. Therefore, for some patients it is better to take Ranitidine, while for others Omeprazole is more suitable.
Which of the described drugs to prefer should be decided by the attending physician. The specialist will help determine which remedy is suitable in this particular case, taking into account the patient’s age, the diagnosed disease, and its severity. And also, taking into account the presence of contraindications and individual intolerance.
In conclusion, we note that you cannot use these, like any other medications, on your own. It must be remembered that any drugs can not only cure, but also seriously harm the body if used incorrectly. Only a specialist can choose the medicine that is right for you. Be healthy!
Suffering from any disease of the gastrointestinal tract, a person almost completely loses his ability to work.
This is due to a change in the frequency of daily bowel movements, the occurrence of pain in the stomach area and other unpleasant symptoms.
Fortunately, the pharmaceutical market offers a wide selection of all kinds of medications that help cope with the symptoms of stomach and intestinal diseases.
One of the most popular medicines this group are Omez, Famotidine and Ranitidine.
What is the difference between them? Which is better to choose: Famotidine or Omez? Can they be taken together?
You will find answers to these and other questions in this article.
Before you decide which option is best for you drug treatment gastrointestinal tract disease, it is worth understanding the mechanism of action of each remedy.
Ranitidine was introduced into pharmacies back in the 1980s. This popular drug does not have a negative effect on intestinal motility.
The action of the medication is aimed at blocking gastric histamine receptors. They are found in the parietal cells of the gastric mucosa.
Thanks to the main active ingredient of the drug, ranitidine, the process of hydrochloric acid production in the gastrointestinal tract slows down.
Reducing stomach acidity promotes rapid recovery.
What should a patient choose - Ranitidine or Omez? Let's consider the medicinal properties of the second drug.
Omez
This is one of the most popular medications intended to relieve symptoms of gastrointestinal ailments such as pancreatitis, gastritis with high acidity, etc.
It is believed that Omez and Ranitidine can be taken together. This is true. However, it is not recommended to prescribe them yourself.
The fact is that incorrect use of Omez can provoke a number of adverse reactions body.
It is rarely prescribed as a primary treatment for stomach disease. Gastroenterologists recommend using Omez for medicinal purposes in complex therapy.
Its main active ingredient is omeprazole, which, like ranitidine, helps reduce gastric acidity.
Therefore, to improve the healing effect, Omez can be taken with Ranitidine.
This medicine acts as an inhibitor of intracellular enzymes. Its second name is proton pump.
A distinctive feature of Omez is that it is prescribed not only for therapeutic, but also for preventive purposes.
It effectively treats and prevents peptic ulcers.
The action of this medication is aimed at inhibiting pathogenic bacteria that contribute to the development and growth of gastric and intestinal ulcers. Thanks to this medicinal properties, Omez is widely used to relieve the symptoms of not only ulcers, but also gastritis.
The medication is quickly absorbed and has a therapeutic effect within 1 hour after entering the stomach.
Thanks to its analgesic properties, Omez helps the patient get rid of discomfort in the abdomen.
The therapeutic analgesic effect lasts throughout the day.
Famotidine
Regardless of which medicine the patient chooses, Famotidine or Omez, the production of hydrochloric acid in his stomach will be suppressed.
Unlike Omez, Famotidine allows you to suppress the activity of pepsin, which is an enzyme in digestive juice.
The mechanism of action of this medication is similar to the previous ones.
It is prescribed for:
- Ulcer of the duodenum and stomach.
- Reflux-Esophagitis.
- Ulcerative lesions of the gastrointestinal tract.
- Zollinger-Ellison syndrome.
- Stress ulcerative lesion.
A distinctive feature of Famotidine is the recommended dosage. Omez or Ranitidine is enough to take 1 time, and Famotidine – 2 times.
This medicine has the same contraindications for use as the previous 2.
Side effects
We found that Ranitidine and Omez can be used together. However, before purchasing one of these medications, it is recommended that you consult your doctor.
Each of them has a number of side effects.
Let's list them:
- Severe headache and dizziness.
- Drowsiness.
- Problems with liver function.
- Malaise and weakness.
- Bloating (flatulence).
- Hives.
- Attack of fever.
- Problems with the functioning of the gastrointestinal tract (diarrhea or constipation).
- Increased sweating.
According to data medical research, the risk of adverse reactions in the body after taking one of these drugs is minimal.
However, some patients exhibited the above symptoms. Their occurrence is associated with 2 factors.
Firstly, with the incorrect use of the medicine (the patient did not carefully read the attached instructions or completely ignored them).
And, secondly, side effects may appear due to medication abuse.
That is why, before taking Famotidine, Omez or Ramotidine, it is recommended to consult a gastroenterologist.
What to choose
Since everyone human body is unique, it is impossible to unambiguously determine which of the medicines we examined will better cope with its therapeutic task.
In each specific case, the choice should be made on a separate medication.
According to people, both Ranitidine and Famotin are excellent drugs for treating diseases of the gastrointestinal tract.
More often they are prescribed for the treatment of peptic ulcers. However, Omez is in no way inferior to them in its medicinal properties.
Each of these drugs allows you to stop the production of excess acid by the stomach, thanks to which the disease can be cured.
Consequently, only a qualified specialist can unequivocally answer the question: which medicine is better to purchase.
To determine drug therapy, he will need to conduct a comprehensive examination of the patient and collect anamnesis.
After that, he will send him for tests. This stage is necessary to make a correct diagnosis. And only after this, the doctor will prescribe a certain medication to his patient.
To relieve pain, in most cases, Omez is prescribed. The drug is quickly absorbed, maintaining the therapeutic effect for more than 1 day.
Thanks to this, Omez is a leader in the sale of medicines for stomach diseases.
The fact is that Omez, like any other non-steroidal drug, has a number of side effects, which cannot be said about Ranitidine.
For this reason, fearing the manifestation of alarming reactions of the body, some patients suffering from gastrointestinal ailments buy Ranitidine.
As for expectant mothers, they are contraindicated to use this drug. However, omeprazole, the main active ingredient of Omez, does not have a harmful effect on the body of a woman and her child.
Therefore, to determine the optimal medication strategy for yourself, it is recommended to undergo a medical examination, and only then purchase medicine.
Useful video
Ranitidine and Omez are antiulcer drugs. What's better?
What is important when choosing a medicine? Price, effectiveness of treatment, presence of contraindications and side effects, history of creation and use of the drug, country/manufacturer?
Of course, the attending physician prescribes the medicine. It is his task to choose the drug appropriate for the patient’s condition. But the patient must also understand why this particular drug is prescribed to him.
Both the doctor and the patient have one main goal of taking the medicine - to cure the disease. Based on this, the following criteria for choosing the best of two drugs can be established:
Compliance of indications for use of the drug and the patient’s diagnosis;
Presence of contraindications to the drug and the patient’s condition;
Side effects of the drug and the balance between the effect of treatment and possible negative consequences from its use;
The effectiveness of the drug, established by the experience of its use in the practice of modern medicine.
The first three criteria are individual and will be applied by the doctor and our reader directly in the process of face-to-face treatment. The fourth criterion can be used to select the best drug.
The effectiveness of the drug may vary in each specific case. Therefore, when choosing, it is worth studying the properties of each drug, the mechanism of its action, side effects and contraindications, main composition, pharmacological group and action.
The effectiveness of a medicine is determined by the action of its main substance. Therefore, it is important to start the comparison here.
Ranitidine
Ranitidine was developed in the eighties of the last century.
The main active ingredient is ranitidine in the form of hydrochloride. It blocks histamine (H2) receptors on parietal cells in the stomach.
This leads to a decrease in the intensity of hydrochloric acid production and its quantity, and a decrease in acidity.
Ranitidine acts for 8-12 hours.
Omez
The main active ingredient is omeprazole. Created in the eighties of the last century by Swedish scientists.
Omez is an inhibitor of one of the intracellular enzymes called the proton pump. Inhibition of this enzyme blocks the formation of hydrochloric acid.
Omez reduces the level of acidity of gastric juice and is also effective for the treatment and prevention of ulcers, as well as inhibition of the bacteria Helicobacter pylori
The advantage of Omez is its speed of action.
Taking 20 mg of the drug every hour reduces the level of gastric acidity; after 2 hours the maximum reduction is achieved.
Omez is valid for 24 hours.
Application
Ranitidine
Used for stomach ulcers and duodenum, ulcers caused by stress, negative effects of medications, and other diseases;
Treatment of inflammation of the esophagus;
With Zollinger-Ellison syndrome;
When performing surgery;
For prevention;
After completing operations.
Omez
Used in similar situations, and in the treatment of pancreatitis, Helicobacter pylori infection, systemic mastocidosis.
Contraindications and side effects
For ulcerative bleeding;
Pregnant and nursing mothers;
Children under 14 years old;
People with hypersensitivity.
Ranitidine should be prescribed with caution to patients with renal and hepatic insufficiency.
Omez has the same contraindications as Ranitidine. It is prescribed with caution to patients with renal and hepatic insufficiency, osteoporosis, and those taking a number of medications.
The list of side effects of Ranitidine is much longer than that of Omez. Its main disadvantage is that its effectiveness decreases when taken repeatedly.
Before starting to use Ranitidine, you should make sure that the patient does not have cancer or ulcers.
So what's better
Omez is a more modern and effective medicine.
Ranitidine, in addition to the disadvantages already mentioned, is not effective enough compared to Omez. It inhibits only histamine receptors, but hydrochloric acid is also formed under the influence of gastrin and acetylcholine.
Another disadvantage of ranitidine is the need to gradually reduce its intake. Otherwise, after stopping Ranitidine, an “acid rebound” may occur - the production of hydrochloric acid in the stomach will increase sharply.
Some sources indicate the low quality of Omez compared to other drugs containing omeprazole. This is true, but the price of these drugs is significantly higher.
Omez made in India is also considered to be of low quality. You can find Omez on the Russian market produced by the Portuguese company Sofarimex Industria Quimica and Farmaceutica.
So, in most cases, Omez is still better than Ranitidine. But the choice of medication should be made by the attending physician based on the results of the examination and taking into account all significant factors.
Equally often used in clinical practice to treat diseases digestive system, one way or another associated with increased secretion of hydrochloric acid by the stomach. Moreover, some experts prefer the first drug, while others prefer the second. Are there any fundamental differences in their application or is it all the result of the “doctor-producer” scheme that is popular today, allowing you to get a significant premium to the current one? wages? What should you buy at the pharmacy: Ranitidine or Omeprazole? How to avoid being deceived and harming yourself for the sake of incompetent specialists? We will try to answer these questions in this article.
How does the stomach produce hydrochloric acid?
In order to understand whether it is better to use Ranitidine or Omez for the treatment of similar diseases, it is necessary to turn to fundamental knowledge from the field of medicine and find out how the process of production of hydrochloric acid in the stomach occurs.
So, hydrochloric acid in the stomach cavity is produced by special parietal cells located in the thickness of the fundic glands. This happens as if under the influence nervous system, potassium ions and hydrogen protons, and with the participation of biologically active substances: histamine, gastrin - increase the acidity of gastric juice and somatostatin - blocks the production of hydrochloric acid in three main phases:
- Cephalic phase. Actually, the beginning of secretion, the triggering factor is the stimulation of the nervous system by the sight, taste or smell of food. The phase begins long before it enters the stomach and serves to prepare the organ for the digestion process;
- Gastric phase. The most significant phase, the factor that triggers it, is the entry of food into the stomach cavity with its subsequent distension. Under the influence of the action of mechanoreceptors of its walls, the production of gastrin by G-cells and histamine by ECL-cells begins, which, in fact, leads to the production of hydrochloric acid;
- Intestinal phase. The final stage begins from the moment food enters the duodenum, which leads to the production of somatostatin and subsequent blocking of the secretion of hydrochloric acid.
Let's pay attention to the mechanism of action
The result of the use of both drugs is a decrease in the acidity of gastric juice, which simultaneously reduces the damaging effect of acid on the walls of organs from various parts of the gastrointestinal tract, and eliminates the associated unpleasant symptoms. However, they act differently: Ranitidine stops the production of histamine, and Omez stops the release of hydrogen protons. In both cases, the secretion of hydrochloric acid is not completely blocked, but only its volumes are reduced, which is good for maintaining the normal functioning of the organ.
At first glance, it may seem that Ranitidine and Omez can be used in all cases where gastric hypersecretion syndrome occurs. But, taking into account that histamine has a more significant effect on the previously described process, and its long-term absence can ultimately lead to atrophy of the corresponding areas of the mucosa and the development of functional digestive disorders, Omez becomes the drug of choice for long-term use. In cases where it is necessary to achieve a more pronounced therapeutic effect in a shorter period of time, Ranitidine should be chosen.
The main advantages and disadvantages of individual drugs
But not only significant (as it turned out) differences in the mechanism of action of drugs can tell you what to choose - Omez or Ranitidine, because each of them has both unique advantages and disadvantages.
Benefits of Ranitidine:
- A domestically produced drug whose effectiveness has been tested over decades of clinical practice;
- Despite numerous statements about its ineffectiveness, in comparison with analogues, Ranitidine performs equally well in all cases of use;
- Low cost, accessibility to all categories of the population;
- Rapid achievement of a therapeutic effect in sufficient volume;
- Complete absence of teratogenic and carcinogenic effects, proven by numerous studies using laboratory animals.
Disadvantages of Ranitidine:
- The drug cannot be used in patients suffering from liver and/or kidney diseases, during pregnancy and in children under 12 years of age;
- Risk of liver dysfunction and lymph formation with long-term use;
- The possibility of developing side effects in the form of dizziness, which may exclude the possibility of driving or engaging in active activities for some time.
The main advantages of Omez over Ranitidine are:
- Possibility of using the drug in patients with renal failure without dose adjustment;
- Production on more advanced and modern equipment;
- Possibility of using the drug for a long time without the risk of atrophy of the gastric mucosa.
The main disadvantages of Omez:
- Impossibility of use in pregnant women and nursing mothers;
- Widespread use of low quality drugs;
- Insufficient experience of use in domestic clinical practice;
- Possibility of buying a counterfeit drug.
Clinical rationale for using Omez instead of Ranitidine
- Ranitidine can be replaced with Omez in cases where, for some reason, the first drug is not well tolerated by patients or often causes side effects;
- The use of Omez is necessary in case of renal impairment, including renal failure of varying severity;
- Omez is the drug of choice for elderly patients;
- Omez should be prescribed if there is a need for constant control of gastric acidity over a long period of time;
- Instead of Ranitidine, Omez can be used even when the pathological process is stopped and the need to achieve a strong therapeutic effect disappears.
Found a mistake? Select it and press Ctrl + Enter
An important place in the treatment of pathologies of the digestive tract is occupied by antiulcer drugs, among which special attention is paid to antisecretory drugs. The most well-known are ranitidine and omeprazole. Let's figure out which of these drugs is more effective, in which cases its use is more appropriate and what advantages/disadvantages it has.
What's the difference?
There are contraindications and side effects, consult your doctor
Despite belonging to the same group, there are differences, as is the case with antacid drugs.
Ranitidine
The drug blocks histamine receptors in the gastrointestinal mucosa (on basal cells), reducing the production of hydrochloric acid, hence the antiulcer effect. A course of treatment is recommended. The dose should be increased if you drink alcohol or smoke. The effectiveness of the drug decreases when combined with.
Indications:
- Treatment of the acute stage of gastric and duodenal ulcers, as well as for prophylactic purposes during remission.
- Gastritis with high acidity.
- Heartburn due to stress and poor nutrition.
- Reflux esophagitis.
- Preparation for gastroscopy.
- Surgical interventions on the stomach.
Contraindications:
- Children under 12 years old.
- Pregnancy and lactation.
- Hypoacid gastritis.
- Individual intolerance.
What is the difference between ranitidine and omeprazole?
Disadvantages include the rapid development of tolerance to standard doses. After discontinuation of the drug, a sharp increase in secretion is observed.
Side effects include: allergic and dyspeptic reactions (flatulence, stool disorders), etc.
Omeprazole
It is an inhibitor of the proton pump, which regulates the concentration of gastric juice. Reduces the activity of peptides and digestive enzymes, thereby providing a prolonged effect. An integral part of Helicobacter pylori eradication.
The difference between omeprazole and ranitidine is that the former not only blocks acid secretion, but also neutralizes its excess. This helps heal erosions and restore damaged cells.
Indications:
- Contraindications and side effects are similar to ranitidine.
Which is better and conclusions
Studies have shown better effectiveness of omeprazole, compared with ranitidine, in the healing of ulcers and the duration of remission after taking high doses of NSAIDs. In addition, it does not require an increase in dosage. Antisecretory activity exceeds H2-blockers by 2-10 times.
Loading...
