Gynepristone is a synthetic steroid drug that is indicated for girls and women of almost any age who are sexually active and have had unprotected sexual intercourse in the last 72 hours.
The product is not suitable for routine contraception, but is effective in some cases.
On this page you will find all the information about Ginepristone: full instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Ginepristone. Would you like to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Antigestagenic drug. Postcoital contraceptive for oral administration.
Conditions for dispensing from pharmacies
Dispensed with a doctor's prescription.
Prices
How much does Gynepristone cost? The average price in pharmacies is 450 rubles.
Release form and composition
One tablet contains:
- active substance: mifepristone -10 mg;
- excipients: microcrystalline cellulose, sodium carboxymethyl starch, calcium stearate.
Tablets from light yellow to light yellow with a greenish tint, flat-cylindrical in shape with a bevel on both sides.
Pharmacological effect
A synthetic steroid antigestagenic drug (blocks the action of progesterone at the receptor level) and does not have gestagenic activity. Antagonism with glucocorticoids is noted (due to competition at the level of communication with receptors).
Increases myometrial contractility by stimulating the release of interleukin-8 in choriodecidual cells and increasing the sensitivity of the myometrium to prostaglandins. Depending on the phase of the menstrual cycle, it inhibits ovulation, changes the endometrium and prevents the implantation of a fertilized egg.
Indications for use
In accordance with the instructions for Ginepristone, mifepristone, the active ingredient of this antigestagenic drug, enhances the contractility of the myometrium, depending on the phase of the menstrual cycle, causes changes in the endometrium, delays ovulation, or prevents the implantation of a fertilized egg.
Considering the described properties of the active component of Ginepristone, the drug is used for emergency post-coital contraception after unprotected sexual intercourse (or if the method used cannot be considered reliable).
Contraindications
The use of Ginepristone is contraindicated in women with a history of the following pathologies:
- Adrenal insufficiency;
- Chronic renal or liver failure;
- Hypersensitivity to the main or one of the auxiliary components of the composition;
- Acute renal or liver failure.
The drug should not be taken after long-term glucocorticosteroid therapy and during breastfeeding.
According to the instructions for Ginepristone, it is recommended to prescribe the drug with caution to patients in the following cases:
- Severe arterial hypertension;
- Hemostasis disorders and after taking anticoagulant drugs;
- Heart rhythm disturbances, chronic heart failure;
- Chronic obstructive pulmonary diseases, including bronchial asthma.
Use during pregnancy and lactation
Gynepristone is contraindicated for use during pregnancy.
Breastfeeding should be stopped for 14 days after taking the drug.
Instructions for use
The instructions for use indicate that Ginepristone is prescribed orally in a single dose of 10 mg (1 tablet) within 72 hours after unprotected sexual intercourse.
To maintain the contraceptive effect, you should refrain from eating 2 hours before using the drug and for 2 hours after taking it.
Gynepristone can be used in any phase of the menstrual cycle.
Side effects
The most common side effects after taking Gynepristone are nausea, lower abdominal pain, dizziness, headache, vomiting, spotting, skin rashes, fever, weakness, menstrual irregularities. Reviews of Ginepristone indicate that after taking the drug there are strong side effects almost never happens.
Before purchasing Gynepristone in pharmacies, you should additionally consult a qualified gynecologist.
Overdose
Clinical observations indicate the absence adverse reactions even when taking 2 g mifepristone. At high dosages, the development of a symptom complex of adrenal insufficiency is possible. Therapy should be carried out by a specialist depending on the manifestations of an overdose.
Special instructions
- Gynepristone does not protect against sexually transmitted diseases, including HIV and other infections.
- Gynepristone is not suitable for permanent contraception - this must be taken into account. It is recommended to take the product after consulting a doctor.
- It is not recommended to take alcohol before taking the drug, and alcoholic beverages should not be consumed within two hours, like other foods and liquids.
After the two-hour period has passed, alcohol is not taken for 24 hours for safety reasons, since its effect may negatively affect the components and the ability to absorb them.
Drug interactions
Simultaneous therapy with Ginepristone and glucocorticosteroids requires dose adjustment with increasing dosages of GCS. The combined use of Ginepristone with NSAIDs is undesirable.
Compatibility of the drug with alcohol
The drug is absolutely incompatible with alcohol. Even a small amount of alcoholic beverages consumed on the day of using the drug can negatively affect the effectiveness.
Ginepristone is available in the form of 10 mg tablets, in cardboard packages, one or two tablets.
The drug contains one active ingredient – mifepristone. Excipients are:
- sodium carboxymethyl starch;
- calcium stearate.
Mifeprestone is a synthetic antagonist of the hormone progesterone, which is also responsible for creating the conditions for pregnancy. Gynepristone blocks the synthesis of this hormone. It also blocks the action of glucocorticoids.
Increases the contractile activity of the uterus, promoting the rejection of the fertilized egg.
Sometimes the drug is prescribed simultaneously with prostaglandin, which mutually enhances its effectiveness.
In addition, the drug is able to inhibit the development of uterine tumors and fibroids.
Indications for use of Ginepristone
The instructions for Ginepristone say that the indications for its use are:
- medical termination of pregnancy early stages(until the 42nd day of delay);
- emergency contraception after unprotected sexual intercourse (up to 72 hours after it);
- therapy for uterine fibroids up to the 12th week of pregnancy;
- preparation for childbirth during full-term pregnancy.
Contraindications
Contraindications to the use of Ginepristone are:
- violation of hemostasis;
- anemia;
- treatment with anticoagulants;
- severe external genital pathology;
- inflammatory diseases of the genital organs;
- presence of a scar on the uterus;
- porphyria;
- acute and chronic renal or liver failure;
- long-term treatment with glucocorticoids;
- dysfunction of the adrenal glands;
- hypersensitivity to the components of the drug.
A relative contraindication to the use of Ginepristone is smoking over the age of 35 without prior consultation with a doctor.
In addition, there are a number of specific contraindications that are taken into account only when treating certain conditions or diseases.
When treating uterine fibroids, contraindications for use are:
- pregnancy;
- lactation;
- submucous location of myoma nodes;
- ovarian tumors;
- endometrial hyperplasia;
- the size of fibroids exceeding 12 weeks of pregnancy.
When preparing and inducing labor, contraindications to the use of the drug are:
- uterine fibroids;
- premature or post-term pregnancy;
- eclampsia and preeclampsia;
- severe gestosis.
When terminating pregnancy, contraindications to the use of Ginepristone are:
- uterine fibroids;
- pregnancy that occurred while taking or after recent discontinuation of oral and intrauterine hormonal contraceptives;
- pregnancy not confirmed by research, or exceeding 42 weeks;
- ectopic pregnancy or suspicion of it.
Take with caution and under medical supervision:
- at cardiovascular diseases and predisposition to them;
- for bronchial asthma and chronic obstructive pulmonary diseases;
Method of administration and dosage of Ginepristone
The instructions for Ginepristone say that it is taken orally according to the following schemes:
For the treatment of uterine fibroids, 50 mg of the drug is taken once, for a course of 3 months.
For emergency postcoital contraception, take 10 mg of the drug (one tablet) in the first 72 hours after unprotected intercourse, regardless of the phase of the menstrual cycle, two hours before eating. You should also refrain from eating for two hours after taking Ginepristone.
To prepare for labor and induce it, take 200 mg of the drug at once, in the presence of a doctor. A day later, take the same dose again.
To terminate a pregnancy, 600 mg of the drug is taken at once, in the presence of a doctor. Misoprostol is taken at the same time. You must remain under medical supervision for two hours after taking it. After two days, ultrasound control is carried out. In case of incomplete abortion or ongoing pregnancy, the vacuum aspiration method is used.
In case of overdose, the development of acute adrenal insufficiency is observed.
Side effects of Gynepristone
Among the nonspecific side effects of Gynepristone are the following:
- skin rashes;
- increase in temperature;
- diarrhea;
- vomiting and nausea;
- dizziness;
- headache;
- weakness;
- feeling of discomfort in the lower abdomen.
In addition to this, when treated with Ginepristone together with misoprostol, the following side effects occur:
- leucorrhoea;
- fainting conditions;
- decrease in hemoglobin;
- anemia;
- anxiety;
- leg pain;
- asthenia;
- insomnia;
- indigestion;
- vaginitis
When interrupting a pregnancy procedure with Ginepristone, the following may additionally occur:
- exacerbation of infections of the uterus and urinary tract;
- inflammation of the uterus and appendages;
- pain in the lower abdomen;
- bleeding.
Among other specific side effects of Gynepristone:
- cycle disorders, amenorrhea (in the treatment of fibroids);
- cycle disorders and bloody discharge from the genital tract (with emergency contraception).
Special instructions
Dispensed by prescription.
Simultaneous use of non-steroidal anti-inflammatory drugs with Ginepristone causes a weakening of its effect.
Taking the drug to terminate a pregnancy or induce labor is possible only in a hospital, since there is a high probability heavy bleeding requiring immediate surgical intervention.
If pregnancy continues after taking Ginepristone, it is necessary to terminate it surgically, since the drug causes fetal malformations.
Does not protect against sexually transmitted diseases.
Analogues of Ginepriston
Among the exact analogues of the drug: Agesta, Pencrofton, Ginesteril, Zhenale, Mifegin and some others.
Terms and conditions of storage
Ginepristone is stored at a temperature not exceeding 30 degrees Celsius, out of the reach of children.
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In this article we will look at the instructions for use and reviews for the drug “Ginepristone”. What kind of drug is this? The birth of a child is a wonderful event when it is wanted and planned. If pregnancy was not planned, but contraception failed, then the drug Ginepristone can help in this situation.
It is therefore advisable to use it only in cases of urgent need.
Reviews of "Ginepristone" are available in large quantities.
Composition and release form of the drug
One tablet of the drug contains 0.01 g of the active substance mifepristone. The excipients include microcellulose, sodium carboxymethyl starch and calcium stearate.
The drug is sold in pharmacies in the form of flat-cylindrical, light yellow tablets weighing 10 mg each. One or two tablets are placed in a blister pack or a polymer jar, which is packed in a cardboard pack.
Reviews from gynecologists about Gynepriston will also be presented.
Mechanism of action of the drug
The drug is a synthetic steroidal antigestagenic agent, that is, it blocks the action of progesterone at the receptor level.
Taking the drug causes an increase in the contractility of the myometrium, stimulates the release of substances that increase its sensitivity to certain types of hormones. The effect of the drug is determined by the phase of the menstrual cycle in which it was taken. Depending on this, the medication inhibits ovulation, changes the endometrium, or prevents an already fertilized egg from implanting.
What else does the instruction tell us about Ginepristone? According to reviews, it is very detailed.
Pharmacokinetics
An hour and a half after taking the drug, the highest concentration of the active substance is observed in the blood. The elimination of the drug in the first 3 days is very slow, then the process noticeably accelerates, and after another 18 hours the drug is completely eliminated from the body.
Indications for use
"Gynepristone" is used as an emergency drug. The drug must be taken within a short time (no more than 72 hours) after sexual intercourse or if the contraceptive used turns out to be unreliable.
According to reviews, Ginepristone is very effective for abortion.
Contraindications
This drug is contraindicated for use in some cases, including:
- high sensitivity to mifepristone;
- adrenal insufficiency or long-term treatment with glucocorticosteroids;
- any form of renal and liver failure;
- in severe form.
It should also be taken with caution for diseases such as:
- various hemostatic disorders, including those associated with previous treatment with anticoagulants;
- chronic obstructive pulmonary diseases;
- severe arterial hypertension;
- diseases associated with heart rhythm disturbances;
- acute and chronic heart failure.
Side effects
According to reviews, Gynepristone can lead to various adverse reactions. Among them are a feeling of discomfort and pain in the lower abdomen, headache, weakness, dizziness, vomiting, nausea, blood from the vagina, menstrual irregularities, fever, and urticaria.
Method of administration and dosage of the drug
It is required to take 1 tablet orally within a maximum of 72 hours after unprotected intimacy. You should abstain from food 2 hours before and after taking the medication.
Apply this medicine possible regardless of the phase of the menstrual cycle, this does not affect the effectiveness of the drug. This is confirmed by doctors' reviews of Ginepristone.
Overdose
Signs of overdose occur when taking a dose of the drug exceeding 2 g. In this case, the likelihood of unwanted side reactions increases. Also, in the case of taking a large dose of Gynepristone, disruption of the adrenal glands is possible, up to the development of adrenal insufficiency.
To treat side effects, symptomatic therapy is prescribed.
Taking the drug simultaneously with non-steroidal anti-inflammatory drugs is contraindicated, since NSAIDs significantly reduce the effectiveness.
Interaction with alcohol
Gynepristone, like most medications, is not recommended to be taken with alcohol. Alcoholic drinks not only enhance unwanted adverse reactions, but also significantly reduce the effectiveness of the product. At least five hours must pass between drinking any alcoholic drink and taking the drug.
Special instructions for use
"Gynepristone", being a means of emergency contraception, is undesirable for use as a means of planned, permanent protection against pregnancy. This drug is also not used to prevent transmission of sexually transmitted diseases, including HIV and AIDS.
It is considered safe to take the drug for emergency termination of pregnancy no more than 2 times a year. This frequency of use does not cause serious complicated reactions, unlike regular use of these tablets or other similar drugs.
Use during pregnancy and lactation
It is contraindicated to take Ginepristone while pregnant. If you need to take the drug during breastfeeding, then you must take a break from breastfeeding for two weeks.
Sold by prescription.
Analogue products
There are the following drugs that act on the body in a similar way to Ginepristone:
- "Ginestril";
- "Genale";
- "Esmiya";
- "Miropriston";
- "Mifegin";
- "Mifepristone";
- "Mifeprex";
- "Pencrofton";
- "Mytholian";
- "Myfotab";
- "Pharmatex";
- "Postinor";
- "Escapelle".
"Ginepristone" has a milder effect on female body than, for example, “Postinor” or “Escapelle”, while not only not inferior to them in efficiency, but often superior to them. It also causes very few side effects, so it is recommended by gynecologists as a safer remedy. At the same time, it is easy to use - you need to take one tablet at once, and not two with an interval of several hours.
Emergency contraception is a good solution if an “unexpected” event occurred, but there were no plans to become pregnant. In such a situation, you can use Ginepristone tablets.
How safe is it? How does the drug work? What are the conditions for its use? - you will find out today, as well as many other things.
Pharmacological action
Ginepristone tablets on a synthetic steroid basis have an antigestagenic effect.
The essence of its action is to block the effects of the hormone progesterone at the receptor level.
The uterus begins to actively contract, releasing some substances. The effect of Ginepristone tablets depends on the phase of the menstrual cycle.
The influence may differ in different periods, which is characterized by:
- Inhibition of ovulation;
- Changes in the endometrium;
- Preventing the implantation of an egg that has already been fertilized.
Photos of the above processes:
Ovulation
The maximum accumulation of the active component in the blood can be observed after 60 minutes to an hour and a half.
First 3 days The elimination of Ginepristone tablets occurs very slowly, but then the process accelerates significantly.
Video on the topic:
Composition and release form
The drug Ginepristone is available in tablet form.
Each tablet contains a concentration of mifepristone of 0.01 g. Used as excipients:
- Microcellulose;
- Sodium carboxymethyl starch;
- Calcium stearate.
Indications for use
The drug Ginepristone is an emergency contraceptive for terminating pregnancy during unprotected sexual intercourse.
Fertilization and further development by day Video about how often you can use emergency contraception and what women need to pay special attention to:
Contraindications
Before starting to take Ginepristone tablets, you must carefully exclude the presence of contraindications.
| No. | Absolute contraindications | Relative contraindications |
|---|---|---|
| 1 | Mifepristone intolerance | Hemostasis disorders |
| 2 | Adrenal insufficiency | Pulmonary diseases of obstructive or chronic type |
| 3 | Long-term use of glucocorticosteroids | Severe arterial hypertension |
| 4 | Acute/chronic renal failure | Arrhythmia |
| 5 | Extragenital pathologies in severe form | Heart failure |
Side effects
Sometimes the use of a drug such as Gynepristone can cause undesirable effects.
| No. | Organ system | Adverse reactions |
|---|---|---|
| 1 | Genitourinary system | Bloody vaginal discharge Failure of the menstrual cycle Endometritis |
| 2 | Nervous system | Dizziness Headaches |
| 3 | Skin and subcutaneous layer | Skin rashes of various types Hives |
| 4 | Organs of the digestive system | Nausea/vomiting Cramping pain in the abdomen Diarrhea |
| 5 | Immune system | Allergic reactions |
| 6 | General | Discomfort in the lower abdomen Feeling weak General malaise Chills Increased body temperature Toxic shock syndrome Painful sensations in the mammary glands |
Drug interactions
Ginepristone tablets should not be mixed with non-steroidal anti-inflammatory drugs, as this may reduce their effectiveness.
Alcohol compatibility
Combining the drug Ginepristone with alcoholic beverages is prohibited, as is eating food during 2 hours.
Useful video:
Dosage and overdose
Only the dose can lead to an overdose more than 2 years, the adrenal glands suffer in this case.
Instructions for use
How to take Gynepristone tablets?
The drug is used exclusively orally in the amount of 1 tablet.
This must be done no later than 72 hours from the moment of unprotected intimacy.
If pregnancy is terminated in this way during two hours You should not consume food before or after taking the pills. Also, the phase of the menstrual cycle is unimportant.
Shelf life and storage of the drug
The drug must be kept for 3 year term in a room with a temperature up to + 30 ̊ C.
Special instructions
Gynepristone tablets cannot be used more than 2 times a year. This scheme is much safer than frequent doses, because the consequences can be different.
The drug does not have the ability to protect against sexually transmitted diseases.
A woman should understand that if there are any disorders of the reproductive system, pregnancy must be excluded after Ginepriston Pregnancy and breastfeeding are a contraindication to the use of Ginepristone tablets.
Ginepristone tablets do not affect attention and reaction speed.
Price
How much does the drug Ginepristone cost? Tablets cost from 160 rubles per piece.
Conditions for dispensing from pharmacies
The drug Ginepristone is sold with a prescription, but can be purchased in some pharmacies without a prescription.
Analogues substitutes
There are a lot of similar drugs. Some of them are more expensive, while others are cheaper.
These include:
- manufactured in the form of tablets with the active ingredient of the same name. Manufacturer: Xianju Green Leaf Pharmaceutical Factory, Hubei Gedian Humanwell Pharmaceutical Co. (China), Obninsk Chemical and Pharmaceutical Company, Izvarino Pharma, Pharmsintez (Russia).
- Mifeprex Available in tablet form based on mifepristone. Manufacturer: Biokhimik (Russia).
- created in the form of tablets with mifepristone. Manufacturer: Mir-pharma (Russia).
- manufactured in tablets based on mifepristone. Manufacturer: Obninsk Chemical and Pharmaceutical Company (Russia).
- Postinor is produced on the basis of levonorgestrel in tablets. Manufacturer: Gedeon Richter (Hungary).
- Pharmatex created in the form of tablets with benzalkonium chloride. Manufacturer: Innothera Chouzy (France).
- Escapelle It is produced in tablets based on levonorgestrel. Manufacturer: Gedeon Richter (Hungary).
Photos of substitutes:
For emergency prevention of pregnancy after pregnancy, Ginepristone tablets can be used, which contain 10 mg of mifepristone, a synthetic steroid.
Ginepristone: instructions for use
The package contains 1 or 2 tablets of the drug. Before use, it is important to understand how Gynepristone works: it blocks receptors, disrupting its regulation in the attachment of a fertilized egg, and also disrupts ovulation, which without progesterone slows down significantly. In addition, the drug leads to thickening of the cervical mucus and creates unfavorable conditions for pregnancy in its cavity.
Gynepristone: indications, contraindications, side effects
- The main indication is the prevention of unwanted pregnancy after unprotected sexual intercourse, for which the drug is taken no later than 72 hours after it.
- Contraindications for use: adrenal insufficiency or taking adrenal hormones, in case of heart failure, or a tendency to thrombus formation. Do not use the drug together with non-steroidal anti-inflammatory drugs. You can breastfeed no earlier than 2 weeks after taking Ginepristone.
- Side effects of the drug - headache and dizziness, vomiting, fever, spotting from the vagina, allergic reaction to Ginepriston.
- The consequences of an overdose of the drug are adrenal insufficiency.
Often women have a question: Postinor or Gynepriston - which is better for emergency pregnancy prevention? If Postinor contains the natural hormone levonorgestrel, then Ginepristone is a synthetic drug that has fewer side effects. It is more reliable for preventing pregnancy, does not lead to disruption of the menstrual cycle and does not depend on its phase. But if a woman took Gynepristone, but her period was delayed, she must take a pregnancy test and be examined by a doctor.
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